Neuronal injury biomarkers for assessment of the individual cognitive reserve in clinically suspected Alzheimer's disease.

ABSTRACT:

Objectives

Many predictive or influencing factors have emerged in investigations of the cognitive reserve model of patients with Alzheimer's disease (AD). For example, neuronal injury, which correlates with cognitive decline in AD, can be assessed by [¹⁸F]-fluorodeoxyglucose positron-emission-tomography (FDG-PET), structural magnetic resonance imaging (MRI) and total tau in cerebrospinal fluid (CSF_t-tau), all according to the A/T/N-classification. The aim of this study was to calculate residual cognitive performance based on neuronal injury biomarkers as a surrogate of cognitive reserve, and to test the predictive value of this index for the individual clinical course.

Methods

110 initially mild cognitive impaired and demented subjects (age 71 ± 8 years

SUBMITTER: Beyer L 

PROVIDER: S-EPMC6699250 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature