The effect of phospho-peptide on the stability of gold nanoparticles and drug delivery.

ABSTRACT:

Background

Gold nanoparticles (AuNPs) have been proposed for many applications in medicine and bioanalysis. For use in all these applications, maintaining the stability of AuNPs in solution by suppressing aggregation is paramount. Herein, the effects of amino acids were investigated in stabilizing AuNPs by rationally designed peptide scaffolds.

Results

Compared to other tested amino acids, phosphotyrosine (pY) significantly stabilized AuNPs. Our results indicated that pY modified AuNPs presented a high level of stability in various solutions, and had good biocompatibility. When a pY-peptide was used in stabilizing AuNPs, the phosphate group could be removed by phosphatases, which subsequently caused the aggregation and the cargo release of AuNPs. In vitro study showed that A

SUBMITTER: Hou Z 

PROVIDER: S-EPMC6699291 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature