Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.

ABSTRACT: The group B Coxsackieviruses (CVB), belonging to the Enterovirus genus, can establish persistent infections in human cells. These persistent infections have been linked to chronic diseases including type 1 diabetes. Still, the outcomes of persistent CVB infections in human pancreas are largely unknown. We established persistent CVB infections in a human pancreatic ductal-like cell line PANC-1 using two distinct CVB1 strains and profiled infection-induced changes in cellular protein expression and secretion using mass spectrometry-based proteomics. Persistent infections, showing characteristics of carrier-state persistence, were associated with a broad spectrum of changes, including changes in mitochondrial network morphology and energy metabolism and in the regulated secretory pathway. Int

SUBMITTER: Lietzen N 

PROVIDER: S-EPMC6699423 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature