Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

To assess effects of increasing omega-3, omega-6, and total polyunsaturated fatty acids (PUFA) on diabetes diagnosis and glucose metabolism.

Design

Systematic review and meta-analyses.

Data sources

Medline, Embase, Cochrane CENTRAL, WHO International Clinical Trials Registry Platform, Clinicaltrials.gov, and trials in relevant systematic reviews.

Eligibility criteria

Randomised controlled trials of at least 24 weeks' duration assessing effects of increasing α-linolenic acid, long chain omega-3, omega-6, or total PUFA, which collected data on diabetes diagnoses, fasting glucose or insulin, glycated haemoglobin (HbA_1c), and/or homoeostatic model assessment for insulin resistance (HOMA-IR).

Data synthesis

Statistical analysis included r

SUBMITTER: Brown TJ 

PROVIDER: S-EPMC6699594 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature