Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell.

ABSTRACT: Many studies about classification and the functional annotation of intrinsically disordered proteins (IDPs) are based on either the occurrence of long disordered regions or the fraction of disordered residues in the sequence. Taking into account both criteria we separate the human proteome, taken as a case study, into three variants of proteins: i) ordered proteins (ORDPs), ii) structured proteins with intrinsically disordered regions (IDPRs), and iii) intrinsically disordered proteins (IDPs). The focus of this work is on the different functional roles of IDPs and IDPRs, which up until now have been generally considered as a whole. Previous studies assigned a large set of functional roles to the general category of IDPs. We show here that IDPs and IDPRs have non-overlapping functional spec

SUBMITTER: Deiana A 

PROVIDER: S-EPMC6699704 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature