Modeling the mutation and reversal of engineered underdominance gene drives.

ABSTRACT: A range of gene drive systems have been proposed that are predicted to increase their frequency and that of associated desirable genetic material even if they confer a fitness cost on individuals carrying them. Engineered underdominance (UD) is such a system and, in one version, is based on the introduction of two independently segregating transgenic constructs each carrying a lethal gene, a suppressor for the lethal at the other locus and a desirable genetic "cargo". Under this system individuals carrying at least one copy of each construct (or no copies of either) are viable whilst those that possess just one of the transgenic constructs are non-viable. Previous theoretical work has explored various properties of these systems, concluding that they should persist indefinitely in absence

SUBMITTER: Edgington MP 

PROVIDER: S-EPMC6699728 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature