Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity.

ABSTRACT: Macrophages accumulate prominently in the visceral adipose tissue (VAT) of obese humans and high fat diet (HFD) fed mice, and this is linked to insulin resistance and type II diabetes. While the mechanisms regulating macrophage recruitment in obesity have been delineated, the signals directing macrophage persistence in VAT are poorly understood. We previously showed that the neuroimmune guidance cue netrin-1 is expressed in the VAT of obese mice and humans, where it promotes macrophage accumulation. To better understand the source of netrin-1 and its effects on adipose tissue macrophage (ATM) fate and function in obesity, we generated mice with myeloid-specific deletion of netrin-1 (Ntn1 ^fl/fl LysMCre ^+/-; Ntn1^Δmac). Interestingly, Ntn1^Δm

SUBMITTER: Sharma M 

PROVIDER: S-EPMC6699780 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature