Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences.

ABSTRACT:

Background

Numerous studies associate adipokines with colorectal malignancy, but few data deal with patients suffering exclusively of rectal carcinoma (RC).

Aims

We evaluated leptin and adiponectin levels in RC patients compared to healthy population and their dynamics after surgery.

Material and methods

Serum leptin and adiponectin were evaluated before surgery in 59 RC consecutive patients (38 males and 21 females), and in age and weight matched healthy controls. Measurements were repeated at 24, 72 hours and 7 days after surgery.

Results

Adipokine levels were higher in women. Controls had higher leptin (32.±4.34 vs 9.51±1.73 ng/ml in women and 11±2.66 vs 2.54±0.39 ng/ml in men, p = 0.00048 and 0.0032) and lower adiponectin (9±0.64 vs 11.85±1.02 μg/ml in wome

SUBMITTER: Florescu A 

PROVIDER: S-EPMC6699797 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature