Associations of the melanocortin 3 receptor C17A + G241A haplotype with body composition and inflammation in African-American adults.

ABSTRACT:

Background

The MC3R haplotype C17A + G241A, which encodes a partially inactivated receptor, has high prevalence in individuals of predominately African ancestry. In pediatric cohorts, homozygosity for this common variant has been associated with obesity, reduced lean mass, and greater fasting insulin. However, metabolic and body composition measures have not been well studied in adults with this haplotype.

Methods

A convenience sample of 237 healthy African-American adult volunteers was studied. TaqMan assays were used to genotype MC3R variants. Labs were drawn in the morning in the fasted state. Body composition data was obtained via dual-energy X-ray absorptiometry. An analysis of covariance was used to examine the associations of genotype with metabolic and body compositi

SUBMITTER: Demidowich AP 

PROVIDER: S-EPMC6699895 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature