Sex differences in the temporal development of pronociceptive immune responses in the tibia fracture mouse model.

ABSTRACT: Previously, distinct sex differences were observed in the pronociceptive role of spinal immune cells in neuropathic and inflammatory mouse pain models. Both peripheral and central innate and adaptive immune changes contribute to sensitization in the tibia fracture rodent model of complex regional pain syndrome, and the current study evaluated sex differences in the development of pronociceptive immune responses after fracture. At 4 and 7 weeks after fracture, the analgesic effects of a microglia inhibitor were tested in male and female mice, and polymerase chain reaction was used to measure inflammatory mediator expression in skin and spinal cord. The temporal progression of complex regional pain syndrome-like changes in male and female wild-type and muMT fracture mice lacking B cells and

SUBMITTER: Guo TZ 

PROVIDER: S-EPMC6699904 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature