Effect of age at menarche on microvascular complications among women with Type 1 diabetes.

ABSTRACT:

Aim

To test the hypothesis that delayed menarche is associated with an increased microvascular complication risk among women with Type 1 diabetes.

Methods

We studied the female participants of an ongoing prospective study of childhood-onset Type 1 diabetes diagnosed during the period 1950-1980. Of 325 women, we included data from 315 who had reached menarche by the study baseline (1986-1988) and who self-reported their age at menarche. Both cross-sectional and prospective analyses over the 25-year follow-up were used to assess the relationship of age at menarche with the prevalence, incidence and cumulative incidence of microvascular complications, comprising overt nephropathy, proliferative retinopathy and confirmed distal symmetric polyneuropathy.

Results

In cross-s

SUBMITTER: Yi Y 

PROVIDER: S-EPMC6699942 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature