Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research.

ABSTRACT: Malaria is caused by Plasmodium parasites and is one of the most life-threatening infectious diseases in humans. Infection can result in severe complications such as cerebral malaria, acute lung injury/acute respiratory distress syndrome, and acute renal injury. These complications are mainly caused by P. falciparum infection and are major causes of death associated with malaria. There are a few species of rodent-infective malaria parasites, and mice infected with such parasites are now widely used for screening candidate drugs and vaccines and for studying host immune responses and pathogenesis associated with disease-related complications. We found that mice of the NC/Jic strain infected with rodent malarial parasites exhibit distinctive disease-related complications such as cerebral mal

SUBMITTER: Ohno T 

PROVIDER: S-EPMC6699971 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature