The role of prediction error and memory destabilization in extinction of cued-fear within the reconsolidation window.

ABSTRACT: Extinction of a cued-fear memory within the reconsolidation window has been proposed to prevent fear reacquisition by reconsolidation interference. This 'retrieval-extinction' procedure has received interest for its therapeutic potential to reduce the impact of fear memories on behavior. To fully exploit its therapeutic potential, it is critical to understand the mechanisms that underlie the 'retrieval-extinction' effect. If the effect depends upon reconsolidation of the original memory, then it would be predicted that destabilization, induced by prediction error, would be critical for observing the effect. Here, the dependency of the retrieval-extinction effect on memory destabilization or prediction error was investigated in pavlovian cued-fear conditioned adult male rats. The requiremen

SUBMITTER: Cahill EN 

PROVIDER: S-EPMC6699995 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature