An Efficient New Process for the Selective Production of Odd-Chain Carboxylic Acids by Simple Carbon Elongation Using Megasphaera hexanoica.

ABSTRACT: The caproate-producing bacterium, Megasphaera hexanoica, metabolizes fructose to produce C₂~C₈ carbon-chain carboxylic acids using various electron acceptors. In particular, odd-chain carboxylic acids (OCCAs) such as valerate (C₅) and heptanoate (C₇), were produced at relatively high concentrations upon propionate supplementation. Using a statistical experimental design method, the optimal culture medium was established for the selective production of OCCAs among the total produced acids. In a medium containing 2.42 g L^-1 sodium acetate and 18.91 g L^-1 sodium propionate, M. hexanoica produced 9.48 g L^-1 valerate, 2.48 g L^-1 heptanoate, and 0.12 g L^-1 caproate. To clarify the metabolism of the

SUBMITTER: Kim H 

PROVIDER: S-EPMC6700076 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature