A comprehensive computational study of amino acid interactions in membrane proteins.

ABSTRACT: Transmembrane proteins play a fundamental role in a wide series of biological processes but, despite their importance, they are less studied than globular proteins, essentially because their embedding in lipid membranes hampers their experimental characterization. In this paper, we improved our understanding of their structural stability through the development of new knowledge-based energy functions describing amino acid pair interactions that prevail in the transmembrane and extramembrane regions of membrane proteins. The comparison of these potentials and those derived from globular proteins yields an objective view of the relative strength of amino acid interactions in the different protein environments, and their role in protein stabilization. Separate potentials were also derived fro

SUBMITTER: Mbaye MN 

PROVIDER: S-EPMC6700154 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature