Bacillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro.

ABSTRACT: Endogenous reactive oxygen species (ROS) are by-products of the aerobic metabolism of cells and have an important signalling role as secondary messengers in various physiological processes, including cell growth and development. However, the excessive production of ROS, as well as the exposure to exogenous ROS, can cause protein oxidation, lipid peroxidation and DNA damages leading to cell injuries. ROS accumulation has been associated to the development of health disorders such as neurodegenerative and cardiovascular diseases, inflammatory bowel disease and cancer. We report that spores of strain SF185, a human isolate of Bacillus megaterium, have antioxidant activity on Caco-2 cells exposed to hydrogen peroxide and on a murine model of dextran sodium sulfate-induced oxidative stress. In

SUBMITTER: Mazzoli A 

PROVIDER: S-EPMC6700169 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature