Focused transcranial ultrasound for treatment of neurodegenerative dementia.

ABSTRACT:

Introduction

Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).

Methods

A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm²) affixed bilaterally was used to target the hippocampus (AD) or substantia nigra (PD) with functional magnetic resonance imaging navigation for enhanced plaque removal. A total of 22 patients (n = 11 AD, n = 11 PD) underwent 8 consecutive, weekly, 1-hour treatments wherein sleep was encouraged naturally or pharmacologically. Cognitive and motor functioning assessment was carried out using standardized evaluations at baseline and conclusion.

Results

Of all, 62.5% of patients

SUBMITTER: Nicodemus NE 

PROVIDER: S-EPMC6700262 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature