Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development.

ABSTRACT: Proper orchestration of T lymphocyte development is critical, as T cells underlie nearly all responses of the adaptive immune system. Developing thymocytes differentiate in response to environmental cues carried from cell surface receptors to the nucleus, shaping a distinct transcriptional program that defines their developmental outcome. Our recent work has identified a previously undescribed role for the vacuolar ATPase (V-ATPase) in facilitating the development of murine thymocytes progressing toward the CD4⁺ and CD8⁺ αβ T cell lineages. Vav1^Cre recombinase-mediated deletion of the a2 isoform of the V-ATPase (a2V) in mouse hematopoietic cells leads to a specific and profound loss of peripheral CD4⁺ and CD8⁺ αβ T cells. Utiliz

SUBMITTER: Peterson TV 

PROVIDER: S-EPMC6700305 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature