Fabrication of an anatomy-mimicking BIO-AIR-TUBE with engineered cartilage.

ABSTRACT:

Introduction

We devised a strategy for the fabrication of an 'anatomy-mimicking' cylinder-type engineered trachea combined with cartilage engineering. The engineered BIOTUBEs are used to support the architecture of the body tissue, for long-segment trachea (>5 cm) with carinal reconstruction. The aim of the present study was to fabricate an anatomy-mimicking cylinder-type regenerative airway, and investigate its applicability in a rabbit model.

Methods

Collagen sponge rings (diameter: 6 mm) were arranged on a silicon tube (diameter: 6 mm) at 2-mm intervals. Chondrocytes from the auricular cartilage were seeded onto collagen sponges immediately prior to implantation in an autologous manner. These constructs were embedded in dorsal subcutaneous pouches of rabbits. One month af

SUBMITTER: Komura M 

PROVIDER: S-EPMC6700413 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature