The Human Gut Microbiome is Structured to Optimize Molecular Interaction Networks.

ABSTRACT: Microbiome studies estimate the functions of bacterial flora in situ on the basis of species composition and gene function; however, estimation of interspecies interaction networks is challenging. This study aimed to develop a method to predict the interaction networks among bacterial species from human gut metagenome data using bioinformatics methods. Our proposed method revealed that adjacent gene pairs involved in bacterial interspecies interactions are localized at boundary regions and encode membrane proteins mediating interactions between the intracellular and extracellular environments, e.g., transporters and channel proteins, and those mediating interactions between metabolic pathways. Actual human gut metagenome data displayed numerous such highly reliable interspecies interaction

SUBMITTER: Ling Y 

PROVIDER: S-EPMC6700418 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature