Ontology highlight
ABSTRACT:
SUBMITTER: Menendez-Gonzalez JB
PROVIDER: S-EPMC6700503 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Stem cell reports 20190801 2
Subversion of transcription factor (TF) activity in hematopoietic stem/progenitor cells (HSPCs) leads to the development of therapy-resistant leukemic stem cells (LSCs) that drive fulminant acute myeloid leukemia (AML). Using a conditional mouse model where zinc-finger TF Gata2 was deleted specifically in hematopoietic cells, we show that knockout of Gata2 leads to rapid and complete cell-autonomous loss of adult hematopoietic stem cells. By using short hairpin RNAi to target GATA2, we also iden ...[more]