Levodopa-Carbidopa Intestinal Gel Monotherapy: GLORIA Registry Demographics, Efficacy, and Safety.

ABSTRACT:

Background

Continuous delivery of levodopa-carbidopa intestinal gel (LCIG) provides stable plasma levodopa concentrations and reduces motor fluctuations in advanced Parkinson's disease (PD) patients.

Objective

To compare the effectiveness and safety of LCIG monotherapy vs polytherapy in patients in the GLORIA registry.

Methods

This was a post hoc analysis of a 24-month, multinational observational registry where advanced PD patients with persistent motor complications received LCIG (with adjunctive PD treatment, as necessary). Patients were categorized retrospectively into three stable treatment groups: LCIG monotherapy, LCIG in combination with oral levodopa only ("levodopa monotherapy" [including nighttime oral levodopa]), or LCIG in combination with any other antip

SUBMITTER: Poewe W 

PROVIDER: S-EPMC6700622 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature