From Perception Threshold to Ion Channels-A Computational Study.

ABSTRACT: Small-surface-area electrodes have successfully been used to preferentially activate cutaneous nociceptors, unlike conventional large area-electrodes, which preferentially activate large non-nociceptor fibers. Assessments of the strength-duration relationship, threshold electrotonus, and slowly increasing pulse forms have displayed different perception thresholds between large and small surface electrodes, which may indicate different excitability properties of the activated cutaneous nerves. In this study, the origin of the differences in perception thresholds between the two electrodes was investigated. It was hypothesized that different perception thresholds could be explained by the varying distributions of voltage-gated ion channels and by morphological differences between peripheral

SUBMITTER: Tigerholm J 

PROVIDER: S-EPMC6700668 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature