Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions.

ABSTRACT: Gastric cancer remains the third leading cause of mortality from cancer worldwide and carries a poor prognosis, due largely to late diagnosis. The importance of the interaction between Helicobacter pylori (H. pylori) infection, the main risk factor, and host-related genetic factors has been studied intensively in recent years. The genetic predisposition for non-hereditary gastric cancer is difficult to assess, as neither the real prevalence of premalignant gastric lesions in various populations nor the environmental risk factors for cancer progression are clearly defined. For non-cardiac intestinal-type cancer, identifying the factors that modulate the progression from inflammation toward cancer is crucial in order to develop preventive strategies. The role of cytokines and t

SUBMITTER: Negovan A 

PROVIDER: S-EPMC6700706 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature