Cell Biology of Intracellular Adaptation of Mycobacterium leprae in the Peripheral Nervous System.

ABSTRACT: The mammalian nervous system is invaded by a number of intracellular bacterial pathogens which can establish and progress infection in susceptible individuals. Subsequent clinical manifestation is apparent with the impairment of the functional units of the nervous system, i.e., the neurons and the supporting glial cells that produce myelin sheaths around axons and provide trophic support to axons and neurons. Most of these neurotrophic bacteria display unique features, have coevolved with the functional sophistication of the nervous system cells, and have adapted remarkably to manipulate neural cell functions for their own advantage. Understanding how these bacterial pathogens establish intracellular adaptation by hijacking endogenous pathways in the nervous system, initiating myelin damag

SUBMITTER: Hess S 

PROVIDER: S-EPMC6700727 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature