Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease.

ABSTRACT: Diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) arise from complex interactions of genetic and environmental factors, with genetic variants regulating individual responses to environmental exposures (i.e. gene-by-environment interactions). Identifying gene-by-environment interactions will be critical to fully understanding disease mechanisms and developing personalized therapeutics, though these interactions are still poorly understood and largely under-studied. Candidate gene approaches have shown that known disease risk variants often regulate response to environmental factors. However, recent improvements in exposome- and genome-wide association and interaction studies in humans and mice are enabling discovery of novel genetic variants and pathways that predict re

SUBMITTER: Dunn AR 

PROVIDER: S-EPMC6700747 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature