In silico prediction of structural changes in human papillomavirus type 16 (HPV16) E6 oncoprotein and its variants.

ABSTRACT:

Background

HPV16 infection is one of the main risk factors involved in the development of cervical cancer, mainly due to the high oncogenic potential of the viral proteins E6 and E7, which are involved in the different processes of malignant transformation. There is a broad spectrum of intratypical variation of E6, which is reflected in its high diversity, biological behavior, global distribution and risk of causing cervical cancer. Experimental studies have shown that the intratypical variants of the protein E6 from the European variants (E-G350, E-A176/G350, E-C188/G350) and Asian-American variants (AAa and AAc), are capable of inducing the differential expression of genes involved in the development of cervical cancer.

Results

An in silico analysis was performed to charac

SUBMITTER: Rodriguez-Ruiz HA 

PROVIDER: S-EPMC6700771 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature