Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites.

ABSTRACT:

Background

African Americans (AAs) experience premature chronic health outcomes and longevity disparities consistent with an accelerated aging phenotype. DNA methylation (DNAm) levels at specific CpG positions are hallmarks of aging evidenced by the presence of age-associated differentially methylated CpG positions (aDMPs) that are the basis for the epigenetic clock for measuring biological age acceleration. Since DNAm has not been widely studied among non-European populations, we examined the association between DNAm and chronological age in AAs and whites, and the association between race, poverty, sex, and epigenetic age acceleration.

Results

We measured genome-wide DNA methylation (866,836 CpGs) using the Illumina MethylationEPIC BeadChip in blood DNA extracted from 487

SUBMITTER: Tajuddin SM 

PROVIDER: S-EPMC6700815 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature