Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD.

ABSTRACT:

Background

Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response plays a critical role in the protection of lung cells to oxidative stress by upregulating antioxidant genes in response to tobacco smoke. There is a critical gap in our knowledge about Nrf-2 regulated genes in active smokers and former-smokers with COPD in different cell types from of lungs and surrogate peripheral tissues.

Methods

We compared the expression of Nrf2 and six of its target genes in alveolar macrophages, nasal, and bronchial epithelium and peripheral blood mononuclear cells (PBMCs) in current and former smokers with COPD. We compared cell-type spe

SUBMITTER: Sidhaye VK 

PROVIDER: S-EPMC6700818 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature