Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Recent evidence suggests that genetic factors are related to the pathogenesis of IgAN. We conducted a genome-wide association study (GWAS) to identify novel genetic susceptibility loci for IgAN in a Korean population.

Methods

We enrolled 188 biopsy-confirmed IgAN cases and 455 healthy controls for the discovery stage and explored associations between IgAN and single nucleotide polymorphisms (SNPs) using a customized DNA chip. The significant SNPs from the discovery samples were then selected for replication in an independent cohort with 310 biopsy-confirmed IgAN cases and 438 healthy controls.

Results

In the first stage, two SNPs (rs10172700 in LOC105373592 and rs22

SUBMITTER: Jeong KH 

PROVIDER: S-EPMC6700823 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature