Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism.

ABSTRACT:

Background

Excessive estrogen exposure is an important pathogenic factor in uterine endometrial cancer (UEC). Recent studies have reported the metabolic properties can influence the progression of UEC. However, the underlying mechanisms have not been fully elucidated.

Methods

Glutaminase (GLS), MYC and autophagy levels were detected. The biological functions of estrogen-MYC-GLS in UEC cells (UECC) were investigated both in vivo and in vitro.

Results

Our study showed that estrogen remarkably increased GLS level through up-regulating c-Myc, and enhanced glutamine (Gln) metabolism in estrogen-sensitive UEC cell (UECC), whereas fulvestrant (an ER inhibitor antagonist) could reverse these effects. Estrogen remarkably promoted cell viability and inhibited autophagy of estro

SUBMITTER: Zhou WJ 

PROVIDER: S-EPMC6700828 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature