Training program-induced skeletal muscle adaptations in two men with myotonic dystrophy type 1.

ABSTRACT:

Objective

The purpose of this side product of another unpublished research project, was to address the effects of a training program on skeletal muscle adaptations of people with myotonic dystrophy type 1 (DM1), under a multifaceted perspective. The objective of this study was to look at training induced muscular adaptations by evaluating changes in muscle strength, myofiber cross-sectional area (CSA), proportion of myofiber types and with indirect markers of muscle growth [proportion of centrally nucleated fibers (CNF) and density of neutrophils and macrophages]. Two men with DM1 underwent a 12-week strength/endurance training program (18 sessions). Two muscle biopsies were obtained pre- and post-training program.

Results

Muscular adaptations occurred only in Patient 1, who

SUBMITTER: Roussel MP 

PROVIDER: S-EPMC6700834 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature