Genetic Variants and the Cortisol Response in Children: An Exploratory Study.

ABSTRACT:

Objective

We examined genomic variation potentially associated with the cortisol stress response in children having a painful medical procedure.

Design

Children 4-10 years old having a peripheral intravenous line inserted provided saliva samples for evaluation of the cortisol response as a biological measure of distress: two on the day of the procedure and two at home on a nonstressful day for comparison values. Children and biological parents also provided samples for genotyping of variants with known or suspected association with the cortisol stress response. Analysis included child-only association and family-based transmission disequilibrium tests (TDTs).

Results

Genotype and phenotype data on the cortisol stress response were available from 326 children for child

SUBMITTER: Ersig AL 

PROVIDER: S-EPMC6700893 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature