Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma is the second most deadly cancer with late presentation and limited treatment options, highlighting an urgent need to better understand HCC to facilitate the identification of early-stage biomarkers and uncover therapeutic targets for the development of novel therapies for HCC.

Methods

Deep transcriptome sequencing of tumor and paired non-tumor liver tissues was performed to comprehensively evaluate the profiles of both the host and HBV transcripts in HCC patients. Differential gene expression patterns and the dys-regulated genes associated with clinical outcomes were analyzed. Somatic mutations were identified from the sequencing data and the deleterious mutations were predicted. Lastly, human-HBV chimeric transcripts were identified, and

SUBMITTER: Jin Y 

PROVIDER: S-EPMC6701074 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature