De novo protein design by citizen scientists.

ABSTRACT: Online citizen science projects such as GalaxyZoo¹, Eyewire² and Phylo³ have proven very successful for data collection, annotation and processing, but for the most part have harnessed human pattern-recognition skills rather than human creativity. An exception is the game EteRNA⁴, in which game players learn to build new RNA structures by exploring the discrete two-dimensional space of Watson-Crick base pairing possibilities. Building new proteins, however, is a more challenging task to present in a game, as both the representation and evaluation of a protein structure are intrinsically three-dimensional. We posed the challenge of de novo protein design in the online protein-folding game Foldit⁵. Players were presented with a fully ext

SUBMITTER: Koepnick B 

PROVIDER: S-EPMC6701466 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature