Animal Models Used to Simulate Retinal Artery Occlusion: A Comprehensive Review.

ABSTRACT:

Purpose

To present an overview of animal models of retinal artery occlusion (RAO).

Methods

Through a systematic literature search in PubMed and Embase, papers describing methods of inducing RAO in animal models were included. The identified methodologic approaches were presented in a narrative synthesis and compared with RAO in humans.

Results

In total, 83 papers reporting on 88 experiments were included. Six different species were used with rodents and monkeys being the most common, and a minority were performed using cats, dogs, rabbits, or pigs. The anatomy of pigs and monkeys resemble that of humans most closely. The two most frequently used methods were laser-induced occlusion or ligation of the arteries. Other methods included raised intraocular pressure, arteri

SUBMITTER: Vestergaard N 

PROVIDER: S-EPMC6701503 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature