Glutathione infusion before primary percutaneous coronary intervention: a randomised controlled pilot study.

ABSTRACT:

Objective

In the setting of reperfused ST-elevation myocardial infarction (STEMI), increased production of reactive oxygen species (ROS) contributes to reperfusion injury. Among ROS, hydrogen peroxide (H₂O₂) showed toxic effects on human cardiomyocytes and may induce microcirculatory impairment. Glutathione (GSH) is a water-soluble tripeptide with a potent oxidant scavenging activity. We hypothesised that the infusion of GSH before acute reoxygenation might counteract the deleterious effects of increased H₂O₂ generation on myocardium.

Methods

Fifty consecutive patients with STEMI, scheduled to undergo primary angioplasty, were randomly assigned, before intervention, to receive an infusion of GSH (2500 mg/25 mL over 10 min), followe

SUBMITTER: Tanzilli G 

PROVIDER: S-EPMC6701599 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature