The effect of H1N1 vaccination on serum miRNA expression in children: A tale of caution for microRNA microarray studies.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of small regulatory RNAs around 21-25 nucleotides in length which govern many aspects of immunity including the host innate and adaptive responses to infection. RT-qPCR studies of select microRNAs show that vaccination alters the expression circulating microRNAs but the effect of vaccination on the global microRNA population (i.e. micronome) has never been studied.

Aim

To describe vaccine associated changes in the expression of microRNAs 21 days after vaccination in children receiving a pandemic influenza (H1N1) vaccination.

Method

Serum samples were obtained from children aged 6 months to 12 years enrolled in an open label randomised control trial of two pandemic influenza (H1N1) vaccines, in which participants received eithe

SUBMITTER: Drury RE 

PROVIDER: S-EPMC6701777 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature