Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis.

ABSTRACT:

Objectives

The aims of this study are to better understand phenotypic differences between male and female rats during sepsis, to characterise the contribution of the beta1-adrenergic blocker landiolol to septic cardiomyopathy and to determine why landiolol induces divergent effects in males and females.

Methods

The myocardial transcriptional profiles in male and female Wistar rats were assessed after the induction of sepsis by cecal ligation and puncture and addition of landiolol.

Results

Our results showed major differences in the biological processes activated during sepsis in male and female rats. In particular, a significant decrease in processes related to cell organisation, contractile function, ionic transport and phosphoinositide-3-kinase/AKT (PI3K/AKT) signal

SUBMITTER: Tran TT 

PROVIDER: S-EPMC6701793 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature