Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro.

ABSTRACT: Gastrin is a peptide hormone, which in combination with other factors such as TGFα, EGF or GLP-1, is capable of increasing beta cell mass and lowering blood glucose levels in adult diabetic mice. In humans, administration of a bolus of gastrin alone induces insulin secretion suggesting that gastrin may target islet cells. However, whether gastrin alone is sufficient to exert an effect on isolated human islets has been controversial and the mechanism remained poorly understood. Therefore, in this study we started to examine the effects of gastrin alone on cultured adult human islets. Treatment of isolated human islets with gastrin I for 48 h resulted in increased expression of insulin, glucagon and somatostatin transcripts. These increases were significantly correlated with the levels of do

SUBMITTER: Lenz A 

PROVIDER: S-EPMC6701795 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature