Intravenous Mannitol Versus Placebo During Partial Nephrectomy in Patients with Normal Kidney Function: A Double-blind, Clinically-integrated, Randomized Trial.

ABSTRACT:

Background

Mannitol is currently used as a renal protective agent to mitigate the effects of renal ischemia during nephron-sparing surgery (NSS). This routine practice lacks rigorous methodological study.

Objective

To assess the effect on renal function outcomes after surgery of mannitol infusion prior to renal ischemia during NSS.

Design, setting, participants

This prospective, randomized, placebo-controlled, double-blind trial included 199 patients with a preoperative estimated glomerular filtration rate (eGFR) >45ml/min/1.73m² scheduled for NSS; the trial was conducted between July 2012 and July 2015.

Intervention

Patients undergoing NSS were randomized to receive mannitol (12.5g) or placebo intravenously within 30min prior to renal vascular clamp

SUBMITTER: Spaliviero M 

PROVIDER: S-EPMC6701857 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature