Genetic and biological characterisation of Zika virus isolates from different Brazilian regions.

ABSTRACT:

Background

Zika virus (ZIKV) infections reported in recent epidemics have been linked to clinical complications that had never been associated with ZIKV before. Adaptive mutations could have contributed to the successful emergence of ZIKV as a global health threat to a nonimmune population. However, the causal relationships between the ZIKV genetic determinants, the pathogenesis and the rapid spread in Latin America and in the Caribbean remain widely unknown.

Objectives

The aim of this study was to characterise three ZIKV isolates obtained from patient samples during the 2015/2016 Brazilian epidemics.

Methods

The ZIKV genomes of these strains were completely sequenced and in vitro infection kinetics experiments were carried out in cell lines and human primary cells.

SUBMITTER: Strottmann DM 

PROVIDER: S-EPMC6701881 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature