Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control.

ABSTRACT: The spinal cord contains a diverse array of interneurons that govern motor output. Traditionally, models of spinal circuits have emphasized the role of inhibition in enforcing reciprocal alternation between left and right sides or flexors and extensors. However, recent work has shown that inhibition also increases coincident with excitation during contraction. Here, using larval zebrafish, we investigate the V2b (Gata3+) class of neurons, which contribute to flexor-extensor alternation but are otherwise poorly understood. Using newly generated transgenic lines we define two stable subclasses with distinct neurotransmitter and morphological properties. These V2b subclasses synapse directly onto motor neurons with differential targeting to speed-specific circuits. In vivo, optogenetic manipu

SUBMITTER: Callahan RA 

PROVIDER: S-EPMC6701946 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature