Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment.

ABSTRACT:

Aim

Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency.

Materials & methods

Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells.

Results

Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free

SUBMITTER: Grillone A 

PROVIDER: S-EPMC6701990 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature