Cerebellar Prediction of the Dynamic Sensory Consequences of Gravity.

ABSTRACT: As we go about our everyday activities, our brain computes accurate estimates of both our motion relative to the world and our orientation relative to gravity. However, how the brain then accounts for gravity as we actively move and interact with our environment is not yet known. Here, we provide evidence that, although during passive movements, individual cerebellar output neurons encode representations of head motion and orientation relative to gravity, these gravity-driven responses are cancelled when head movement is a consequence of voluntary generated movement. In contrast, the gravity-driven responses of primary otolith and semicircular canal afferents remain intact during both active and passive self-motion, indicating the attenuated responses of central neurons are not inherited f

SUBMITTER: Mackrous I 

PROVIDER: S-EPMC6702062 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature