Biomaterializing the promise of cardiac tissue engineering.

ABSTRACT: During an average individual's lifespan, the human heart pumps nearly 200 million liters of blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that native myocardium under this incredible demand is extraordinarily complex, both structurally and functionally. As a result, successful engineering of adult-mimetic functional cardiac tissues is likely to require utilization of highly specialized biomaterials representative of the native extracellular microenvironment. There is currently no single biomaterial that fully recapitulates the architecture or the biochemical and biomechanical properties of adult myocardium. However, significant effort has gone toward designing highly functional materials and tissue constructs that may one day provide a ready source

SUBMITTER: Pomeroy JE 

PROVIDER: S-EPMC6702110 | biostudies-literature | 2020 Sep - Oct

REPOSITORIES: biostudies-literature