ASIC3-dependent metabolomics profiling of serum and urine in a mouse model of fibromyalgia.

ABSTRACT: Fibromyalgia (FM) is characterized by chronic widespread pain. The pathogenesis of FM remains unclear. No specific biomarkers are available. Animal models of FM may provide an opportunity to explore potential biomarkers in a relative homogenous disease condition. Here, we probed the metabolomics profiles of serum and urine in a mouse model of FM induced by intermittent cold stress (ICS). We focused on the role of acid-sensing ion channel 3 (ASIC3) in the metabolomics profiling because ICS treatment induced chronic widespread muscle pain lasting for 1 month in wild-type (Asic3^+/+) but not Asic3-knockout (Asic3^-/-) mice. Serum and urine samples were collected from both genotypes at different ICS stages, including before ICS (basal level) and post-ICS at days 10 (middle

SUBMITTER: Hsu WH 

PROVIDER: S-EPMC6702159 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature