Cholecystectomy Risk in Crohn's Disease Patients After Ileal Resection: a Long-term Nationwide Cohort Study.

ABSTRACT:

Background

The risk of gallstone disease necessitating cholecystectomy after ileal resection (IR) in Crohn's disease (CD) patients is not well established. We studied the incidence, cumulative and relative risk of cholecystectomy after IR in CD patients, and associated risk factors.

Methods

CD patients with a first IR between 1991 and 2015 were identified in PALGA, a nationwide pathology database in the Netherlands. Details on subsequent cholecystectomy and IR were recorded. Yearly cholecystectomy rates from the general Dutch population were used as a reference.

Results

A cohort of 8302 (3466 (41.7%) males) CD patients after IR was identified. During the 11.9 (IQR 6.3-18.0) years median follow-up, the post-IR incidence rate of cholecystectomy was 5.2 (95% CI 3.5-6.4)/

SUBMITTER: Goet JC 

PROVIDER: S-EPMC6702183 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature