Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition.

ABSTRACT: Influenza viruses are a serious threat to human health, causing numerous deaths and pandemics worldwide. To date, neuraminidase (NA) inhibitors have primarily been used to treat influenza. However, there is a growing need for novel NA inhibitors owing to the emergence of resistant viruses. Geranii Herba (Geranium thunbergii Siebold et Zuccarini), which is edible, has long been used in a variety of disease treatments in Asia. Although recent studies have reported its various pharmacological activities, the effect of Geranii Herba and its components on influenza viruses has not yet been reported. In this study, Geranii Herba ethanol extract (GHE) and its component geraniin showed high antiviral activity against influenza A strain as well as influenza B strain, against which oseltamivir has l

SUBMITTER: Choi JG 

PROVIDER: S-EPMC6702199 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature