A lesion and connectivity-based hierarchical model of chronic aphasia recovery dissociates patients and healthy controls.

ABSTRACT: Traditional models of left hemisphere stroke recovery propose that reactivation of remaining ipsilesional tissue is optimal for language processing whereas reliance on contralesional right hemisphere homologues is less beneficial or possibly maladaptive in the chronic recovery stage. However, neuroimaging evidence for this proposal is mixed. This study aimed to elucidate patterns of effective connectivity in patients with chronic aphasia in light of healthy control connectivity patterns and in relation to damaged tissue within left hemisphere regions of interest and according to performance on a semantic decision task. Using fMRI and dynamic causal modeling, biologically-plausible models within four model families were created to correspond to potential neural recovery patterns, including

SUBMITTER: Meier EL 

PROVIDER: S-EPMC6702239 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature